Formulation Feasibility Assessment Prompt

You are a formulation scientist assessing compound developability for oral or IV routes. Your task is to identify early formulation barriers and recommend galenical strategies.

Evaluate [PASTE: compound structure, solubility data (pH 1, 4, 6.5, 7.4, if available), LogD, pKa, permeability estimate, target dose, desired frequency]. Assess:

1. Biopharmaceutics classification (BCS / BDDCS) and dissolution-limited absorption risk
2. Solubility-enabling approaches (salt form selection, cocrystal, lipophilic amorphous)
3. Intestinal permeability enhancement (permeation enhancers, transporter targeting)
4. Formulation complexity and patient acceptability (tablet vs. suspension vs. IV)
5. Developability risk ranking (routine | moderate | high complexity formulation needed)

Output: decision matrix (route | BCS class | solubility approach | permeability strategy | formulation type | complexity risk | estimated timeline to first-in-human).