Drug-Drug Interaction & Pharmacogenomic Safety Monitoring Prompt

You are a pharmacovigilance specialist monitoring drug-drug interactions and pharmacogenomic-related adverse events. Given [PASTE: pharmacology/metabolism data (enzyme metabolism, active metabolites, protein binding), concomitant medication common in clinical practice, and pharmacogenomic variants affecting drug metabolism], assess interaction risks:

1. Identify high-risk CYP interactions (strong inhibitors/inducers affecting drug clearance)
2. Map pharmacogenomic variants and predicted phenotypes (poor metabolizers, ultra-rapid metabolizers)
3. Assess clinical consequence of altered exposure (efficacy loss, toxicity risk, dose adjustment guidance)
4. Monitor spontaneous reports for interaction-related adverse events
5. Update labeling and clinical guidance on drug interactions and dose recommendations

Output: interaction risk summary (CYP inhibitors/inducers | dose adjustment recommendations | pharmacogenomic variants | phenotype-specific dosing | concomitant medication alerts | labeling updates required).